H. Phillip Koeffler, MD
Division of Hematology/Oncology
Cedars-Sinai Medical Center
University of California at Los Angeles School of Medicine
8700 Beverly Blvd,5431
Los Angeles
California, USA
koeffler@cshs.org

Present Position

• Director, Division of Hematology/Oncology
  Cedars-Sinai Medical Center/UCLA School of Medicine
  8700 Beverly Blvd., 5431
  Los Angeles, CA 90048
  
• Professor of Medicine
  Division of Hematology/Oncology
  University of California, Los Angeles
  Los Angeles, California
  
• Holder of The Mark Goodson Chair in Oncology Research Cedars-Sinai Medical Center
• Professor of Bioengineering
  University of California Los Angeles
  Los Angeles, CA
  
• Deputy Director of Cancer Research/ Senior Consultant
  +Department of Hematology-Oncology, NCIS
  National University of Singapore
• Senior Principal Investigator of Cancer Science Institute of Singapore
  National University of Singapore

Societies

• American Association for Cancer Research
• American Association of Hematology
• American Association for the Advancements of Science
• American Society Clinical Oncology
• Member of International CCN Society

Research Theme

• CCN proteins: study the pro-growth effects of CYR61 and CTGF in a number of human cancers including Brain, lung cancer.
  Furthermore studying the importance of RUNX2 in a frequent amplicon in human osteosarcomas.

Selected Recent Publications

• Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
  Gain-of-function of mutated c-Cbl tumor suppressor associated with myeloid neoplasms with 11q UPD.
  Nature, 460(7257):904-8, 2009
• Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, Song JH, Yin D, Toh M, Xie WD, Said JW and Koeffler.
  Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.
  Cancer Research, 69(14):5876-84, 2009.
• Thoennissen NH, O’Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R and Koeffler HP.
  Capsaicin causes cell cycle arrest and apoptosis in ER-positive and –negative breast cancer cells by modulating the EGFR/HER-2 pathway.
  Oncogene,29(2):285-96, 2010.
• Cao Q, Gery S, Dashti A, Yin D, Zhou Y, Gu J, and Koeffler HP.
  A role for the clock gene per1 in prostate cancer.
  Cancer Res. 69(19):7619-25, 2009.
• Akagi T, shih LY, Ogawa S, Gerss J, Moore SR, Schreck R, Kawamata N, Liang DC, Sanada M, Nannya Y, Deneberg S, Zachariadis V, Nordgren A, Song JH, Dugas M, Lehmann S and Koeffler HP.
  Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.
  Haematologica. 94(9):1301-6, 2009.
• Thoenissen NH, Krug UO, Lee DH, Kawamata N, Iwanski GB, Lasho T, Weiss T, Nowak D, Koren-Michowitz M, Kato M, Sanada M, Shih LY, Nagler A, Raynaud SD, Muller-Tidow C, Mesa R, Haferlach T, Gilliland DG, Tefferi A, Ogawa S, and Koeffler HP.
  Prevelence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.
  Blood 115(14):2882-90, 2010.
• Nowak D, Ogawa S, Müschen M, Kato M, Kawamata N, Meixel A, Nowak V, Kim HS, Kang S,Paquette R, Chang MS, Thoenissen NH, Mossner M, Hofmann WK, Kohlmann A, Weiss T, Haferlach, T, Haferlach C, Koeffler HP.
  SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations.
  Blood. 115(5):1049-53, 2010.
• Gery S, Koeffler HP.
  Circadian rhythms and cancer.
  Cell Cycle. 23;9(6), 2010.
• Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS.
  Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
  Nat Genet. 42(6):492-4, 2010.
• Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon SM, Polo JM, Valls E, Klemm L, Shojaee S, Cerchietti L, Schuh W, Jäck HM, Hurtz C, Ramezani-Rad P, Herzog S, Jumaa H, Koeffler HP, de Alborán IM, Melnick AM, Ye BH, Müschen M.
  BCL6 is critical for the development of a diverse primary B cell repertoire.
  J Exp Med. 207(6):1209-21. 2010.
• Yin D, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said JW, Black KL, Koeffler HP.
  CTGF associated with oncogenic activities and drug resistance in glioblastoma multiforme (GBM).
  Int J Cancer. 2010, 127(10):2257-67.
• Lilljebjörn H, Soneson C, Andersson A, Heldrup J, Behrendtz M, Kawamata N, Ogawa S, Koeffler HP, Mitelman F, Johansson B, Fontes M, Fioretos T.
  The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias.
  Hum Mol Genet. 2010 19(16):3150-8.
• Ogawa S, Shih LY, Suzuki T, Otsu M, Naikauch H, Koeffler HP, Sanada M.
  Deregulated Intracellular Signaling by Mutated c-CBL in Myeloid Neoplasms.
  Clin Cancer Res. 2010 16: 3825-3831.
• Gueller S, Goodridge HS, Niebuhr B, Xing H, Koren-Michowitz M, Serve H, Underhill DM, Brandts CH, Koeffler HP.
  Adaptor protein Lnk inhibits c-Fms-mediated macrophage function.
  J Leukoc Biol. 2010, 88(4):699-706.
• Akagi T, Thoennissen NH, George A, Crooks G, Song JH, Okamoto R, Nowak D, Gombart AF, Koeffler HP.
  In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
  PLoS One. 2010 Nov 3;5(11):e15419.
• Koeffler HP.
  Is there a role for differentiating therapy in non-APL AML?
  Best Pract Res Clin Haematol. 2010 Dec;23(4):503-8