Member

Paul Bornstein, MD
Department of Biochemistry
Box 357350
University of Washington
Seattle, WA 98195 - USA
bornsten@u.washington.edu

Present Position

Professor of Biochemistry and Medicine, University of Washington

Societies

• American Society of Biochemistry and Molecular Biology
• American Society for Cell Biology
• American Society for Clinical Investigation
• Western Society for Clinical Research
• American Chemical Society
• American Rheumatism Association
• Association of American Physicians

Awards and honors

• Phi Beta Kappa
• 1954 B.A. with honors in all subjects, Cornell University
• 1954-1958 New York State Regents Scholarship in Medicine
• 1956 Wertheim Award, New York University School of Medicine
• 1958 Faculty Journal Club Award, New York University School of Medicine
• 1968-1971 Lederle Medical Faculty Award
• 1969-1974 Research Career Development Award
• 1967; 1970; 1973 Travel Awards, International Congress of Biochemistry
• 1974 Association of American Physicians
• 1975 Josiah Macy Faculty Scholar Award
• 1985 John Simon Guggenheim Memorial Fellowship
• 1989 MERIT Award, National Institute of Arthritis, Musculoskeletal and Skin Diseases
• 2001-2003 President, International Society for Matrix Biology
• 2001-2003 Vice-President and President-elect, American Society for Matrix Biology
• 2003- 2004 President, American Society for Matrix Biology
• 2004 Solomon Berson Alumni Achievement Award in Basic Science, New York University School of Medicine

Recent Publications

• Yang, Z., Kyriakides, T.R.,Bornstein, P.
  Matricellular proteins as modulators of cell-matrix interactions: the adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2.
  Mol. Biol. Cell 2000;11:3353-3364.
• Bornstein, P.
  Thrombospondins as matricellular modulators of cell function.
  J. Clin. Invest. 2001; 107:929-934.
• Yang, Z., Strickland, D.K., Bornstein, P.
  Extracellular MMP2 levels are regulated by the LRP scavenger receptor and thrombospondin 2.
  J. Biol. Chem. 2001;276:8403-8408.
• Kyriakides, T.R., Hartzell, T., Huynh, G., Bornstein, P.
  Regulation of angiogenesis and matrix remodeling by localized, matrix-mediated antisense gene delivery.
  Molecular Therapy 2001; 3:842-849.
• Bornstein, P.,Sage, E.H.
  Matricellular proteins: extracellular modulators of cell function.
  Current Opin. Cell Biol. 2002;14:608-616.
• Lange-Asschenfeldt, B., Weninger, W., Velasco, P., Kyriakides, T., von Andrian, U.H., Bornstein, P., Detmar, M.
  Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2 deficient mice.
  Blood 2002; 99:538-545.
• Bornstein, P., Walsh, V., Tullis, J., Stainbrook, E., Bateman, J.,Hormuzdi, S.G.
  The globular domain of the proa1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice.
  J. Biol. Chem. 2002; 277:2605-2613.
• Agah, A., Kyriakides, T.R., Lawler, J., and Bornstein, P.
  The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice.
  Am. J.Path. 2002; 161:831-839.
• Kyriakides, T.R., Rojnuckarin, P., Reidy, M.A., Hankenson, K.D., Papayannopoulou, T., Kaushansky, K., Bornstein, P.
  Megakaryocytes require thrombospondin 2 for normal platelet formation and function.
  Blood 2003; 101:3915-3923.
• Bornstein, P., Agah, A., Kyriakides, T.R.
  The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury.
  Int. J. Biochem. Cell Biol. 2004;36:1115-1125.
• Rahkonen, O., Su, M., Hakovirta, H., Koskivirta, I., Hormuzdi, S.G., Vuorio, E., Bornstein, P.,Penttinen, R.
  Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture.
  Circ. Res. 2004; 94:83-90.
• Kyriakides, T.R., Foster, M.J., Keeney, G.E., Tsai, A., Giachelli, C.M., Clark-Lewis, I., Rollins, B.J.,Bornstein, P.
  The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation.
  Am. J. Pathol. 2004;165: 2157-2166,.
• Christopherson, K,S., Ullian, E.M., Stokes, C.C.A., Mulloowney, C.E., Agah, A., Lawler, J., Mosher, D.F., Bornstein, P., Barres, B.A.
  Thrombospondins are astrocyte proteins that promote CNS synaptogenesis.
  Cell 2005; 120: 421-433.
• Hankenson, K.D., Hormuzdi, S.G., Meganck, J.A.,Bornstein, P.
  Mice with a disruption of the thrombospondin 3 gene differ in geometric and biochemical properties of bone and have accelerated development of the femoral head.
  Mol. Cell. Biol. 2005; 25: 5599-5606.
• Agah, A., Kyriakides, T.R.,Bornstein, P.
  Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice.
  Am. J. Path. 2005; 167: 81-88.
• Chen, J., Somanath, P.R., Razorenova, O., Chen, W.S., Hay, N., Bornstein, P., Byzova, T.
  Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
  Nature Medicine. 2005; 11:1188-1196.
• Oganesian, A., Au, S., Horst, J.A., Holzhausen, L. C., Macy, A. J., Pace, J. M., and Bornstein, P.
  The NH2-Terminal propeptide of type I procollagen acts intracellularly to modulate cell function.
  J. Biol. Chem. 2006; 281: 3807-3815.
• Kopp, H-G, Hooper, A.T., Broekman, M.J., Avecilla, S.T., Petit, I., Luo, M., Milde, T., Ramos, C.A. Zhang, H., Jopp, T., Bornstein, P., Lawler, J., Jin, D.K., Marcus, A.J.,Rafii, S
  Thrombospondins deployed by thrombopoetic cells determine angiogenic switch and extent of revascularization.
  J. Clin. Invest. 2006; 116:3277-3291.
• Lamy, L., Foussat, A., Brown, E.J., Bornstein, P., Ticchioni, M.,Bernard, A.
  Interactions between CD47 and thrombospondin reduce inflammation.
  J. Immunol. 2007; 178: 5930-5939