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President-elect

Masaharu Takigawa

Masaharu Takigawa, PhD
Department of Biochemistry and Molecular Dentistry
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
2-5-1, Shikata-cho, Okayama, 600-8525,
JAPAN
Tel: 81-86-235-6645
Fax: 81-86-235-6649
http://www.dent.okayama-u.ac.jp/seika/index_sc_e.html
takigawa@md.okayama-u.ac.jp

Present Position

Professor, Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Societies

  • The International CCN Society (First member)
  • International Bone and Mineral Society
  • Japanese Society of Cartilage Metabolism (board of directors)
  • Japanese Society for Bone and Mineral Metabolism (councilor, board of directors -2007)
  • Japanese Association for Oral Biology (councilor, board of directors -2006)
  • The Japanese Biochemical Society (councilor)
  • Japanese Society for Connective Tissue Research (councilor)
  • The Japanese Vascular Biology and Medicine Organization (councilor)
  • The Molecular Biology Society of Japan
  • The Japanese Cancer Association
  • Japan Society for Cell biology
  • American Society for Bone and Mineral Research
  • American Society for Biochemistry and Molecular Biology
  • American Association for Cancer Research

Awards

  • 1992 Scientific Award from Japanese Society for Bone and Mineral Metabolism
  • 1997 Promotion Award of Bone and Joint Disease from the Japan Rheumatism Foundation

Editorial Boards

  • Journal of Cell Communication and Signaling (Associate editor)
  • Journal of Oral Biosciences (Editor in Biochemistry)
  • Journal of Orthopaedic Science (Editorial board)
  • Journal of Bone and Mineral Metabolism (Advisory board)

Current Research

  • The roles of CCN proteins in skeletal growth and regeneration
  • CCN2 actions in angiogenesis and tumor growth
  • Skeletal Biology

Selected Recent Publications

  • Kubota S. and Takigawa M.
     CCN. Encyclopedia of Signaling Molecules (Choi S. ed.), Springer, 2010, in press
  • Nishida T, Emura K, Kubota S, Lyons KM, Takigawa M.
    CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).　
    J. Bone Miner. Res., 2010 Aug 18. [Epub ahead of print]
  • Mukudai Y, Kubota S, Eguchi T, Sumiyoshi K, Janune D, Kondo S, Shintani S, Takigawa M.
    A coding RNA segment that enhances the ribosomal recruitment of chicken ccn1 mRNA. 
    J. Cell. Biochem. 2010;111:1607-18
  • Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Nishida T, Shimo T, Yamashiro T, Takigawa M. 
    Identification of miR-1 as an miRNA that supports late-stage differentiation of growth cartilage cells.
    Biochem. Biophys. Res. Commun., 2010;402:286-90
  • Perbal A. Takigawa M, Perbal B. 
    CCN Proteins in Health and Diseases,
    Springer, Dordrecht, 2010, pp.1-338
  • Kawaki H, Kubota S, Aoyama E, Fujita N, Hanagata H, Miyauchi A, Nakai K, Takigawa M.  Design and utility of CCN2 anchor peptide aptamers.　
    Biochimie. 2010;92:1010-5
  • Takeuchi H, Kubota S, Murakashi E, Zhou Y, Endo K, Ng PS, Takigawa M, Numabe Y. 
    Nicotine-induced CCN2: from smoking to periodontal fibrosis. 
    J. Dent Res. 2010;34-9.
  • Sumiyoshi K, Kubota, S, Furuta, RA, Tasui K, Aoyama, E, Kawaki H, Kawata, K, Ohgawara T, Yamashiro T, Takigawa M. 
    Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and pletelet maturation via CCN2. 
    J. Cell Commun. Signal. 2010;4:5-14.
  • Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M.
    N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan. 
    Biochem. J. 2009;420:413-420.
  • Sakai Y, Balam TA, Kuroda S, Tamamura N, Fukunaga T, Takigawa M, Takano-Yamamoto T.
    CTGF and apoptosis in mouse osteocytes induced by tooth movement. 
    J. Dent. Res. 2009;88:345-50.
  • Ohgawara, T., Kubota, S., Kawaki, H., Kondo, S., Eguchi, T., Kurio, N., Aoyama, E., Sasaki, A. Takigawa, M.
    Regulation of chondrocytic phenotype by micro RNA 18a: Involvement of Ccn2/Ctgf as a major target gene.
    FEBS Lett. 2009;583:1006-10.
  • Maeda, A., Nishida, T., Aoyama, E., Kubota, S., Lyons, K. M., Kuboki, T., Takigawa, M.
    CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor, which action regulayes the proliferation and differentiation of chondrocytes. 
    J. Biochem. 2009;145:207-16.
  • Nishida, T. Kondo, S., Maeda, A., Kubota, S., Lyons, K. M., Takigawa, M.
    CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1a expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition.
    Bone  2009;44:24-31.
  • Takeuchi, H., Kubota, S., Murakashi, E., Fukada, T., Hashimoto, S., Takigawa, M. and Numabe, Y. 
    Effect of TGF-β1 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells.
    J. periodontal. Res., 2009;44:161-169. 
  • Mukudai, Y., Kubota, S., Kawaki, H., Kondo, S. Eguchi, T., Sumiyoshi, K., Ohgawara, T., Shimo, T., Takigawa, M. 
    Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.
    Mol. Cell Biol. 2008;28:6134-47.
  • Kawaki H , Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons K, Takigawa M
    Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 revealed by a comprehensive analysis of the CCN family proteins in cartilage
    J. Bone Miner. Res. 2008;23:1751-64.
  • Eguchi T, Kubota S, Kawata K, Mukudai Y, Uehara J, Ohgawara T, Ibaragi S, Sasaki S, Kuboki T, and Takigawa M
    Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene
    Mol. Cell. Biol. 2008;28:2391-413.
  • Kikuchi T, Kubota, S, Asaumi K, Kawaki H, Nishida T, Kawata K, Mitani S, Tabata Y, Ozaki T, and Takigawa M
    Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel
    Tissue Eng. Part A 2008;14:1089-98
  • Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, and Kuboki T
    Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.
    Cell Transplantation 2008;17:231-40.
  • Fujisawa T, Hattori T, Ono M, Uehara J, Kubota, S, Kuboki T, and Takigawa M
    CCN family 2 / Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes.
    Osteoarthritis Cartilage 2008;16:787-95
  • Kawaki H, Kubota S, Suzuki A, Yamada T, Matsumura T, Mandai T, Yao M, Maeda T, Lyons KM, Takigawa M.
    Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.
    Biochem. Biophys. Res. Commun. 2008;366:450-6.
  • Oka M, Kubota S, Kondo S, Eguchi T, Kuroda C, Kawata K, Minagi S, Takigawa M.
    Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation.
    J. Histochem. Cytochem. 2007;55:1245-55.
  • Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, and Kurabayashi M
    Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
    Eur. J. Heart Fail. 2008;10:373-9.
  • Kubota S, and Takigawa M
    Role of CCN2/CTGF/Hcs24 in Bone Growth.
    Int. Rev. Cytol. 2007; 147: 1-41. Review.
  • Kubota S, and Takigawa M
    CCN2 Molecule Page UCSD/Nature. The Signaling Gateway. 2007; AfCS ID A003961:
    URL:     http://www.signaling-gateway.org/molecule/query?afcsid=A003961
  • Kubota S, and Takigawa M
    CTGF (connective tissue growth factor). Atlas Genet Cytogenet Oncol Haematol. 2007; CTGFID40192.
    URL:     http://AtlasGeneticsOncology.org/Genes/CTGFID40192ch6q23.html
  • Kubota S, Takigawa M.
    CCN family proteins and angiogenesis: from embryo to adulthood.
    Angiogenesis. 2007;10:1-11. Review.
  • Kubota S, Yeger H, Perbal B, Takigawa M.
    Report on the fourth international workshop on the CCN family of genes.
    J. Cell Commun. Signal. 2007 Jun;1:59-65.
  • Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, Fujioka M, Sudo A, Uchida A, Yamamoto S, Ozaki K, Takigawa M, Tanaka T, Nakamura Y, Jiang Q, Ikegawa S.
    A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.
    Nat. Genet. 2007; 39:529-33. Epub 2007 Mar 25.
  • Eguchi T, Kubota S, Kawata K, Mukudai Y, Ohgawara T, Miyazono K, Nakao K, Kondo S, and Takigawa M
    Different transcriptional strategies of ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.
    Biochimie, 2007; 89: 278-288
  • Yanagita T, Kubota S, Kawata K, Kawaki H, Kondo S, Takano-Yamamoto T, Tanaka S. and Takigawa M
    Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes
    FEBS J. 2007; 274:1655-1665.
  • Koitabashi N, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, and Kurabayashi M
    Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis.
    Hypertension 2007; 49:1120-1127.
  • Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T.
    Promotion of attachment of human bone marrow stromal cells by CCN2.
    Biochem. Biophys. Res. Commun. 2007;357(1):20-5.
  • Nishida T, Kawaki H, Baxter RM, Deyoung RA, Takigawa M, Lyons KM.
    CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
    J. Cell Commun. Signal. 2007 ;1(1):45-58.
  • Kondo S, Kubota S, Moritani N, Yosimichi G, Nishida T, Matsushita H, Matsumoto S, Kitoh T, Nakao K, Sugahara T, and Takigawa M
    Hypoxic Regulation of Stability of Connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
    Oncogene 2006; 25:1099-1110.
  • Shimo T, Kubota S, Eguchi T, Ibaragi S, Isowa S, Yoshioka N, Sasaki A, and Takigawa M
    Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer.
    J. Bone Miner. Res. 2006; 21:1045-1059.
  • Yosimichi G, Kubota S, Nishida T, Kondo S, Yanagita T, Nakao K, Takano-Yamamoto T, and Takigawa M
    Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
    Bone 2006; 38:853-863.
  • Kondo S, Tanaka N, Kubota S, Mukudai Y, Yosimichi G, Sugahara T, and Takigawa M
    Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF) in human endothelial cells.
    Mol. Cancer Ther. 2006; 5:129-137.
  • Perbal, B. and Takigawa, M. (Editors)
    CCN Proteins : A New Family of Cell Growth and Differentiation Regulators. Imperial College Press, London, 2005, 1-311
  • Mukudai Y, Kubota S, Eguchi T, Kondo S, Nakao K, Takigawa M.
    Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative trans-factor during differentiation of chondrocytes.
    J. Biol. Chem. 2005;280(5):3166-77. Epub 2004 Nov 18.
  • Nishida T, Kubota S, Kojima S, Kuboki T, Nakao K, Kushibiki T, Tabata Y, Takigawa M.
    Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).
    J. Bone Miner. Res. 2004;19(8):1308-19.
  • Yokoi H, Mukoyama M, Nagae T, Mori K, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Nishida T, Takigawa M, Sugawara A, Nakao K.
    Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis.
    J. Am .Soc. Nephrol. 2004 Jun;15(6):1430-40.
  • Takigawa M, Nakanishi T, Kubota S, Nishida T.
    The role of CTGF/Hcs24/ecogenin in skeletal growth control.
    J. Cell. Physiol. 2003;194(3):256-66. Review.
  • Takigawa M
    CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes, and vascular endothelial cells.
    Drug News Perspect. 2003;16(1):11-21. Review.