Margarete Goppelt-Struebe, PhD 

Department of Nephrology and Hypertension,
Universitätsklinikum Erlangen
University of Erlangen-Nuremberg,
Loschgestr. 8, D-91054 Erlangen, Germany
Tel.: 49-9131-853 92 01
FAX: 49-9131-853 92 02
margarete.goppelt-struebe@uk-erlangen.de

Present Position

• Professor of Molecular Pharmacology

Societies

• German Society for Pharmacology and Toxicology
• German Society for Biochemistry and Molecular Biology
• American Association for Biochemistry and Molecular Biology,
• The Biochemical Society UK
• Signal Transduction Society
• International CCN Society

Editorial Boards

• Section Editor: BMC Cell Biology

Research Themes

• Regulation of connective tissue growth factor in vitro and in vivo
• Plasticity of tubular epithelial cells
• Characterization of the expression of fibrosis-associated proteins
• Modulation of gene expression by alterations of the cytoskeleton

Recent publications

• Kroening S, Goppelt-Struebe M.
  Analysis of matrix-dependent cell migration with a barrier migration assay.
  Sci Signal. 2010 Jun 15;3(126):pl1.
• Komorowsky C, Samarin J, Rehm M, Guidolin D, Goppelt-Struebe M.
  Hic-5 as a regulator of endothelial cell morphology and connective tissue growth factor gene expression.
  J. Mol. Med. 2010: 88:623-631.
• Kroening, S., Stix, J., Keller, C., Streiff, C., Goppelt-Struebe, M.
  Matrix-independent stimulation of human tubular epithelial cell migration by Rho kinase inhibitors.
  J. Cell. Physiol. 2010 Jun;223(3):703-712.
• Schietke RE, Warnecke C, Wacker I, Schodel J, Mole DR, Campean V, Amann K, Goppelt-Struebe M, Behrens J, Eckardt KU, Wiesener MS.
  The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia - insights into cellular transformation processes mediated by HIF-1.
  J. Biol. Chem. 2010 Feb 26;285(9):6658-6669.
• Samarin J, Wessel J, Cicha I, Kroening S, Warnecke C, Goppelt-Struebe M.
  FOXO proteins mediate hypoxic induction of connective tissue growth factor (CTGF) in endothelial cells.
  J. Biol. Chem. 2010 Feb 12;285(7):4328-4336.
• Kroening S., Neubauer E., Wullich B., Aten J., Goppelt-Struebe M.
  Characterization of Connective Tissue Growth Factor Expression in Primary Cultures of Human Tubular Epithelial Cells: Modulation by Hypoxia.
  Am. J. Physiol. Renal Physiol. 2010 Mar;298(3):F796-806.
• Kroening S., Neubauer E., Wessel J., Wiesener M., Goppelt-Struebe M.
  Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines.
  Nephrol. Dial. Transplant. 2009; 24(11):3319-25.
• Cicha I., Beronov K., Ramirez E.L., Osterode K., Goppelt-Struebe M., Raaz D., Yilmaz A., Daniel W.G., Garlichs C.D.
  Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-alpha and monocytic cell recruitment in a simplified model of arterial bifurcations.
  Atherosclerosis. 2009; 207:93-102.
• Samarin J, Cicha I, Goppelt-Struebe M.
  Cell type-specific regulation of connective tissue growth factor protein expression by PI3K – AKT – FoxO signaling.
  J. Cell Commun. Signaling; 2009; 3:79-84.
• Komorowsky, C., Ocker, M., Goppelt-Struebe, M.
  Differential Regulation of Connective Tissue Growth Factor in Renal Cells by Histone Deacetylase Inhibitors.
  J. Cell. Mol. Med. 2009; 13:2353-2364
• Samarin, J., Rehm, M., Krueger, B., Waschke, J., Goppelt-Struebe, M.
  Upregulation of connective tissue growth factor (CTGF/CCN2) in endothelial cells by the microtubule destabilizing agent combretastatin A-4. Mol.
  Cancer Res. 2008, accepted;. 2009; 7:180-188
• Kroening, S, Solomovitch, S, Sachs, M, Wullich, B, Goppelt-Struebe, M.
  Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells.
  Nephrol Dial Transplant. 2009;24(3):755-62.
• Giehl K., Graness A., Goppelt-Struebe M.
  The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression.
  Am J Physiol Renal Physiol. 2008; 294:F407-13.
• Gauer S., Hauser I.A., Obermüller N., Holzmann Y., Geiger H., Goppelt-Struebe M.
  Synergistic induction of osteopontin by aldosterone and inflammatory cytokines in mesangial cells.
  J. Cell. Biochem. 2008; 103:615-23
• Cicha, I., Goppelt-Struebe, M., Muehlich, S., Yilmaz, A., Raaz, D., Daniel, WG., Garlichs, CD.
  Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress.
  Atherosclerosis. 2008;196:136-145