John Castellot, Ph.D.
Department of Anatomy and Cell Biology
Tufts University School of Medicine
136 Harrison Avenue
Boston MA 02111, USA
Tel: 1 617 636 0303
Fax: 1 617 636 0304
john.castellot@tufts.edu
www.tufts.edu/sackler/cmdb/castellot-lab.htm

Present Position

• Professor of Anatomy and Cell Biology
  Professor of Pharmacology and Experimental Therapeutics
  Director, Program in Cell, Molecular and Developmental Biology
  Tufts University School of Medicine

Societies

• American Society for Cell Biology
• American Society for Biochemistry and Molecular Biology
• American Society for Investigative Pathology
• International CCN Society

Editorial Boards

• Journal of Cell Communication and Signaling

Research Themes

• CCN proteins in cardiovascular disease, uterine fibroids, asthma and other smooth muscle cell-based diseases
• Regulation of smooth muscle cell proliferation

Recent Publications

• Gray MR, Malmquist JA, Sullivan M, Blea M, and Castellot JJ
  CCN5 Expression in Mammals. II. Adult Rodent Tissues
  J. Cell Commun. Signal. 2007; 1:145-158
• Malmquist JA, Gray MR, Oliveira, BE, Koch M, and Castellot JJ
  CCN5 Expression in Mammals. I. Embryonic and Fetal Tissues of Human and Mouse
  J. Cell Commun. Signal. 2007; 1:127-14
• Gray M and Castellot JJ
  Regulation of Smooth Muscle Cell Growth
  Uterine Fibroids: Pathogenesis and Management. Brosens I, ed. London: Taylor and Francis, 2006; pp. 25-41.
• Gray M and Castellot JJ
  Biology and Pathophysiology of CCN5
  The CCN Family of Proteins. Perbal B, and Takigaw M. eds. Imperial College Press, 2005; pp. 247-265.
• Mason HR, Wubben M, Nowak RA, Lake AC, and Castellot JJ
  The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells
  Molec Human Reproduction 2004; 10:1-7.
• Mason HR, Grove-Strawser D, Nowak RA, Rubin R, and Castellot JJ
  Estrogen induces CCN5 expression in the rat uterus in vivo.
  J Endocrinology 2004; 145: 976-982.
• Lake AC and Castellot JJ
  CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells
  Cell Commun. Signal. 2004; 1:5-12.
• Lake AC and Castellot JJ
  CCN5 is a growth arrest-specific gene that inhibits vascular smooth muscle cell proliferation and motility
  Amer J Pathol. 2003; 162: 219-231
• Mishra-Gorur K, Singer H and Castellot JJ
  The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II in vascular smooth muscle cells
  J Biol Chem. 2002; 277:33527-40