David R. Brigstock, PhD
Children's Research Institute
Children's Hospital
700 Children's Drive
Columbus Ohio 43205 USA
Tel: 1 614-722-2840
Fax: 1 614-722-2716
David.Brigsto@pediatrics.ohio-state.edu

Present Position

• Professor, Departments of Surgery and Molecular & Cellular Biochemistry,
  Ohio State University
  Columbus Ohio 43212

Societies

• Society of Biology (Fellow)
• International CCN Society (former Scientific vice-chair)6
• American Association for the Study of Liver Diseases
• International Society for Hepatic Sinusoidal Research
• American Society for Cell Biology
• The Endocrine Society
• Society of University Surgeons (elected)

Editorships

• USA Editor, Journal of Endocrinology
• Editorial board member, Journal of Cell Communication and Signaling

Research Themes

• Structure-function studies of CCN2
• Role of CCN2 in hepatic and pancreatic fibrosis
• Regulation and action of CCN2 in hepatic or pancreatic stellate cells
• CCN2 transgenic models
• In vivo delivery and effects of CCN2 siRNA
• MicroRNA regulation of CCN2 production
• Regulation of CCN2 production by HCV

Selected Publications

• Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M
  Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and cell proliferation 
  Mol Endocrinol 2009 23:324-36.
• Lawrenica C, Charrier A, Huang G and Brigstock DR 
  Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells
  Growth Factors 2009; 27 :91-99
• Wang J, Leclercq, Brymore JM, Ramezani-Mogadam M, London RM, Brigstock DR, George J .
  Kupffer cells mediate leptin-induced liver fibrosis
  Gastroenterology 2009; 137:713-723
• Tong Z, Brigstock, D.R..
  Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor. 
  J. Endocrinol 2006;188 R1-R8
• Gao, R. and Brigstock, D.R.
  A novel integrin α5β1 binding domain in module 4 of connective tissue growth factor promotes adhesion and migration of activated pancreatic stellate cells. 
  Gut 2006;55 856-862
• Rachfal AW and Brigstock, D.R. .
  CCN proteins in liver injury and disease.
  In "CCN proteins: a new family of cell growth regulators," B. Perbal and M. Takigawa, Eds. Imperial College Press, UK. 2005; pp 117-134
• Gao, R. and Brigstock, D.R..
  Activation of nuclear factor-kappaB (NF-kB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells.
  Cell Comm Signal 2005; 3:14 doi:10.1186/1478-811X-3-14
• Gao R and Brigstock D.R..
  Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: Integrin α5β1 as a novel CCN2 receptor.
  Gastroenterology 2005;129 2019-2030
• Rachfal AW and Brigstock, D.R. .
  Structural and functional properties of CCN proteins.
  Vitamins and Hormones 2005; 70 69-103
• Gao R., Brigstock D.R. .
  Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its carboxyl-terminal domain to integrin αvβ3 and heparan sulfate proteoglycans.
  J Biol Chem 2004;279 8848-8855
• Gao R, Ball DK, Perbal B, Brigstock D.R. .
  Connective tissue growth factor (CCN2) induces c-fos gene activation and cell proliferation through p44/42 MAP kinase (ERK1/2) in primary rat hepatic stellate cells.
  J. Hepatol 2004;40 431-438
• Gao R, Brigstock D.R. .
  Low-density lipoprotein receptor-related protein is a heparin- dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells.
  Hepatol Res 2003;27 214-220
• Ball, D.K., Moussad, E.E-D.A., Rageh, M.A.E., Kemper, S.A, Brigstock, D.R. .
  Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero.
  Reproduction 2003;125 271-284
• Ball DK, Wilson AW, Kemper SA, Brigstock D.R..
  The heparin-binding 10kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.
  J Endocrinol 2003;176 R1-R7
• Brigstock, D.R., Steffen, C.L. Kim, G.Y., Vegunta, R.K. Diehl, J.R. and Harding P.A..
  Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids: Identification as heparin-regulated 10,000-Mr forms of connective tissue growth factor.
  J. Biol. Chem. 1997; 272 20275-20282